Our Technology

BIO 300 – A Unique, Highly Selective Radiation Modulator

BIO 300 is being developed as a radiation modulator for multiple indications and has been extensively studied as a potential cancer therapeutic and as a radioprotectant.  It was the subject of a research program conducted by the Armed Forces Radiobiology Research Institute where its radioprotective effects were confirmed.  The active ingredient in BIO 300 is a small molecule with limited solubility and poor oral bioavailability, which prevents absorption of therapeutic doses without proper formulations. Humanetics has developed a patented, stable nano-particle formulation that greatly improves oral bioactivity (see Pharmacokinetic Data).

BIO 300 has a variety of biological effects, which leads to its unique efficacy as a radiation modulator. These include effects on cell cycle regulation, oxidative stress and inflammation. (see Mechanism of Action).

BIO 300's unique mechanism allows it to selectively protect normal tissues and to avoid protection of tumor cells.  BIO 300 is in a Phase I/II clinical trial in patients undergoing radiochemotherapy for non-small cell lung cancer.  See more about this trial.