Relevant Publications

Oncology

Jackson IL, Pavlovic R, Alexander AA, Connors CQ, Newman D, Mahmood J, Eley J, Harvey AJ, Kaytor MD, Vujaskovic Z. BIO 300, a nanosuspension of genistein, mitigates radiation-induced erectile dysfunction and sensitizes human prostate cancer xenografts to radiation therapy. International Journal of Radiation Oncology. 2019;105(2):400-409. PubMed PMID: 31175904.

Zhang J, Su H, Li Q, Li J, Zhao Q. Genistein decreases A549 cell viability via inhibition of the PI3K/AKT/HIF-1a/VEGF and NF-kb/COX-2 signaling pathways. Molecular Medicine Reports 2017;15(4):2296-2302. PubMed PMID: 28259980.

Fang Y, Zhang Q, Wang X, Yang X, Wang X, Huang Z, Jiao Y, Wang J. Quantitative phosphoproteomics reveals genistein as a modulator of cell cycle and DNA damage response pathways in triple-negative breast cancer cells. International Journal of Oncology. 2016;48(3):1016-28. PubMed PMID: 26783066

Liu X, Sun C, Liu B, Jin X, Li P, Zheng X, Zhao T, Li F, Li Q. Genistein mediates the selective radiosensitizing effect in NSCLC A549 cells via inhibiting methylation of the keap1 gene promoter region. Oncotarget. 2016;7(19):27267-79. PubMed PMID: 2702907

Thomas CG, Strom A, Lindberg K, Gustafsson JA. Estrogen receptor beta decreases survival of p53-defective cancer cells after DNA damage by impairing G(2)/M checkpoint signaling. Breast Cancer Research and Treatment. 2011;127(2):417-27. PubMed PMID: 206231

Matsumura K, Tanaka T, Kawashima H, Nakatani T. Involvement of the estrogen receptor beta in genistein-induced expression of p21(waf1/cip1) in PC-3 prostate cancer cells. Anticancer Research. 2008;28(2A):709-14. PubMed PMID: 18507011.

Medical Countermeasures

Landauer MR, Harvey AJ, Kaytor MD, Day RM. Mechanism and therapeutic window of a genistein nanosuspension to protect against hematopoietic-acute radiation syndrome. Journal of Radiation Research. 2019;60(3):308-317. PubMed PMID: 31038675

Jones JW, Jackson IL, Vujaskovic Z, Kaytor MD, Kane MA. Targeted metabolomics identifies pharmacodynamic biomarkers for BIO 300 mitigation of radiation-induced lung injury. Pharmaceutical Research. 2017;34(12):2698-2709. PubMed PMID: 28971289.

Jackson IL, Zodda A, Gurung G, Pavlovic R, Kaytor MD, Kuskowski MA, Vujaskovic Z. BIO 300, a nanosuspension of genistein, mitigates pneumonitis/fibrosis following high-dose radiation exposure in the C57L/J murine model. British Journal of Pharmacology. 2017;174(24):4738-50. PubMed PMID: 28963717.

Ha CT, Li XH, Fu D, Xiao M, Landauer MR. Genistein nanoparticles protect mouse hematopoietic system and prevent proinflammatory factors after gamma irradiation. Radiation research. 2013;180(3):316-25. PubMed PMID: 23952576.

Calveley VL Jelveh S, Langan A, Mahmood J, Yeung IW, Van Dyke J, Hill RP. Genistein can mitigate the effect of radiation on rat lung tissue. Radiation Research. 2010;173(5):602-11. PubMed PMID: 20426659.

Background and Mechanism of Action

Cheema AK, Mehta KY, Santiago PT, Fatanmi OO, Kaytor MD, Singh VK. Pharmacokinetic and metabolomic studies with BIO 300, a nanosuspension of genistein, in a nonhuman primate model. International Journal of Molecular Sciences. 2019;20(5):1231. PubMed PMID: 30870965.

Warner M, Huang B, Gustafsson JA. Estrogen receptor beta as a pharmaceutical target. Trends in Pharmacological Sciences. 2017;38(1):92-99. PubMed PMID: 27979317.

Manas ES, Xu ZB, Unwalla RJ, Somers WS. Understanding the selectivity of genistein for human estrogen receptor-beta using X-ray crystallography and computational methods. Structure. 2004;12(12):2197-207. PubMed PMID: 15576033.

Routledge EJ, White R, Parker MG, Sumpter JP. Differential effects of xenoestrogens on coactivator recruitment by estrogen receptor (ER) alpha and ERbeta. Journal of Biological Chemistry. 2000;275(46):35986-93. PubMed PMID: 10964929.

Kuiper GG, Lemmen JG, Carlsson B, Corton JC, Safe SH, van der Saag PT, van der Burg B, Gustafsson JK. Interaction of estrogenic chemicals and phytoestrogens with estrogen receptor beta. Endocrinology. 1998;139(10):4252-63. PubMed PMID: 9751507.