Relevant Publications


Fang Y, Zhang Q, Wang X, Yang X, Wang X, Huang Z, Jiao Y, Wang J. Quantitative phosphoproteomics reveals genistein as a modulator of cell cycle and DNA damage response pathways in triple-negative breast cancer cells. International journal of oncology. 2016;48(3):1016-28.

Liu X, Sun C, Liu B, Jin X, Li P, Zheng X, Zhao T, Li F, Li Q. Genistein mediates the selective radiosensitizing effect in NSCLC A549 cells via inhibiting methylation of the keap1 gene promoter region. Oncotarget. 2016. Epub 2016/03/31. doi: 10.18632/oncotarget.8403. PubMed PMID: 27029077.

Thomas CG, Strom A, Lindberg K, Gustafsson JA. Estrogen receptor beta decreases survival of p53-defective cancer cells after DNA damage by impairing G(2)/M checkpoint signaling. Breast Cancer Res Treat. 2011;127(2):417-27. Epub 2010/07/14. doi: 10.1007/s10549-010-1011-z. PubMed PMID: 20623183.

Matsumura K, Tanaka T, Kawashima H, Nakatani T. Involvement of the estrogen receptor beta in genistein-induced expression of p21(waf1/cip1) in PC-3 prostate cancer cells. Anticancer research. 2008;28(2A):709-14. PubMed PMID: 18507011.

Medical Countermeasures

Michael R Landauer, Adam J Harvey, Michael D Kaytor, Regina M Day, Mechanism and therapeutic window of a genistein nanosuspension to protect against hematopoietic-acute radiation syndrome, Journal of Radiation Research, , rrz014

Jones JW, Jackson IL, Vujaskovic Z, Kaytor MD, Kane MA. Targeted Metabolomics Identifies Pharmacodynamic Biomarkers for BIO 300 Mitigation of Radiation-Induced Lung Injury. Pharmaceutical research. 2017. doi: 10.1007/s11095-017-2200-9. PubMed PMID: 28971289.

Jackson IL, Zodda A, Gurung G, Pavlovic R, Kaytor MD, Kuskowski MA, Vujaskovic Z. BIO 300, a nanosuspension of genistein, mitigates pneumonitis/fibrosis following high-dose radiation exposure in the C57L/J murine model. British journal of pharmacology. 2017. Epub 2017/10/01. doi: 10.1111/bph.14056. PubMed PMID: 28963717.

Ha CT, Li XH, Fu D, Xiao M, Landauer MR. Genistein nanoparticles protect mouse hematopoietic system and prevent proinflammatory factors after gamma irradiation. Radiation research. 2013;180(3):316-25. Epub 2013/08/21. doi: 10.1667/rr3326.1. PubMed PMID: 23952576.

Background and Mechanism of Action

Warner M, Huang B, Gustafsson JA. Estrogen Receptor beta as a Pharmaceutical Target. Trends Pharmacol Sci. 2016. doi: 10.1016/ PubMed PMID: 27979317.

Manas ES, Xu ZB, Unwalla RJ, Somers WS. Understanding the selectivity of genistein for human estrogen receptor-beta using X-ray crystallography and computational methods. Structure. 2004;12(12):2197-207. doi: 10.1016/j.str.2004.09.015. PubMed PMID: 15576033.

Routledge EJ, White R, Parker MG, Sumpter JP. Differential effects of xenoestrogens on coactivator recruitment by estrogen receptor (ER) alpha and ERbeta. The Journal of biological chemistry. 2000;275(46):35986-93. doi: 10.1074/jbc.M006777200. PubMed PMID: 10964929.

Kuiper GG, Lemmen JG, Carlsson B, Corton JC, Safe SH, van der Saag PT, van der Burg B, Gustafsson JK. Interaction of Estrogenic Chemicals and Phytoestrogens with Estrogen Receptor beta. Endocrinology. 1998;139(10):4252-63. doi: 10.1210/endo.139.10.6216. PubMed PMID: 28200438.